diff --git a/backends/qualcomm/quantizer/annotators/htp_rules.py b/backends/qualcomm/quantizer/annotators/htp_rules.py
index 14775b6600a..c68e855856e 100644
--- a/backends/qualcomm/quantizer/annotators/htp_rules.py
+++ b/backends/qualcomm/quantizer/annotators/htp_rules.py
@@ -842,15 +842,18 @@ def annotate(node: Node, quantization_config: QuantizationConfig) -> None:
         input_qspec_map = {}
         input_qspec = quantization_config.input_activation
         output_qspec = None
-        if input_qspec is not None:
+        if input_qspec is not None and _is_float_tensor(value):
             input_qspec_map[value] = input_qspec
             output_qspec = SharedQuantizationSpec((value, node))
 
-        node.meta[Q_ANNOTATION_KEY] = QuantizationAnnotation(
-            input_qspec_map=input_qspec_map,
-            output_qspec=output_qspec,
-            _annotated=True,
-        )
+        # A non-float value leaves nothing to quantize; leave the node unannotated
+        # rather than marking it annotated with an empty spec (its output stays non-float).
+        if len(input_qspec_map) > 0 or output_qspec is not None:
+            node.meta[Q_ANNOTATION_KEY] = QuantizationAnnotation(
+                input_qspec_map=input_qspec_map,
+                output_qspec=output_qspec,
+                _annotated=True,
+            )
 
 
 @register_annotator(
diff --git a/backends/qualcomm/quantizer/annotators/lpai_rules.py b/backends/qualcomm/quantizer/annotators/lpai_rules.py
index 95864f308ce..fa68a9d3d8c 100644
--- a/backends/qualcomm/quantizer/annotators/lpai_rules.py
+++ b/backends/qualcomm/quantizer/annotators/lpai_rules.py
@@ -466,13 +466,20 @@ def annotate(node: Node, quantization_config: QuantizationConfig) -> None:
         value = node.args[2]
 
         input_qspec_map = {}
-        input_qspec_map[value] = quantization_config.input_activation
-
-        node.meta[Q_ANNOTATION_KEY] = QuantizationAnnotation(
-            input_qspec_map=input_qspec_map,
-            output_qspec=SharedQuantizationSpec((value, node)),
-            _annotated=True,
-        )
+        output_qspec = None
+        input_qspec = quantization_config.input_activation
+        if input_qspec is not None and _is_float_tensor(value):
+            input_qspec_map[value] = input_qspec
+            output_qspec = SharedQuantizationSpec((value, node))
+
+        # A non-float value leaves nothing to quantize; leave the node unannotated
+        # rather than marking it annotated with an empty spec (its output stays non-float).
+        if len(input_qspec_map) > 0 or output_qspec is not None:
+            node.meta[Q_ANNOTATION_KEY] = QuantizationAnnotation(
+                input_qspec_map=input_qspec_map,
+                output_qspec=output_qspec,
+                _annotated=True,
+            )
 
 
 @register_annotator(
diff --git a/backends/qualcomm/tests/test_passes.py b/backends/qualcomm/tests/test_passes.py
index 7ba0e4f9de1..9004deda4f1 100644
--- a/backends/qualcomm/tests/test_passes.py
+++ b/backends/qualcomm/tests/test_passes.py
@@ -470,6 +470,54 @@ def test_decompose_hardsigmoid_backend_aware(self):
                         f"hardsigmoid {'should' if should_decompose else 'should NOT'} be decomposed for {backend.name}",
                     )
 
+    def test_index_put_int64_value_not_quantized(self):
+        """QNN's IndexPut annotator must skip a non-float (int64) value arg.
+
+        Regression for MoE (Mixtral) routing, where index_put's value is an int64
+        arange: annotating it makes quantize_per_tensor assert a float input, so
+        to_executorch() fails. Only float tensors may be annotated.
+        Exercised on both the HTP and LPAI annotators, which share the guard.
+        """
+
+        class IndexPutInt64Value(torch.nn.Module):
+            def forward(self, x):
+                buf = torch.zeros(4, dtype=torch.long)
+                idx = torch.arange(
+                    4, dtype=torch.int64
+                )  # int64 value written by index_put
+                buf = buf.index_put((torch.tensor([0, 1, 2, 3]),), idx)
+                return x + buf.to(torch.float32)
+
+        module = IndexPutInt64Value().eval()
+        sample_input = (torch.randn(4),)
+
+        def run_backend(backend):
+            quantizer = QnnQuantizer(backend=backend)
+            quantizer.set_default_quant_config(quant_dtype=QuantDtype.use_8a8w)
+            gm = (
+                torch.export.export(module, sample_input)
+                .run_decompositions({})
+                .module()
+            )
+            prepared = prepare_pt2e(gm, quantizer)
+            prepared(*sample_input)
+            converted = convert_pt2e(prepared)
+            # Re-export runs the quantize_per_tensor meta kernel; before the dtype
+            # guard this raised "Expecting input to have dtype torch.float32" on the
+            # int64 value.
+            torch.export.export(converted, sample_input)
+
+        # HTP is the core QNN quantizer backend; a failure here is a real regression,
+        # not something to swallow. LPAI additionally needs quantized_aot_lib, so only
+        # that missing optional dependency is allowed to skip the LPAI leg.
+        run_backend(QnnExecuTorchBackendType.kHtpBackend)
+        try:
+            run_backend(QnnExecuTorchBackendType.kLpaiBackend)
+        except Exception as e:
+            if "quantized_aot_lib" in str(e):
+                self.skipTest(f"LPAI quantizer unavailable: {e}")
+            raise
+
 
 if __name__ == "__main__":
     unittest.main()